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4 edition of Developmental regulation of the voltage gated sodium channel in PC12G cells found in the catalog.

Developmental regulation of the voltage gated sodium channel in PC12G cells

Sandeep Raha

Developmental regulation of the voltage gated sodium channel in PC12G cells

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  • 35 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.)--University of Toronto, 1990.

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches.
ID Numbers
Open LibraryOL14890444M
ISBN 100315583991
OCLC/WorldCa30970861

  Start studying Learning objectives Apr Neurons. Learn vocabulary, terms, and more with flashcards, games, and other study tools. a single extension that transmits signals to other cells. voltage gated sodium channels open, then potassium voltage gated channels open, sodium closes, potassium is slow to close. In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis Djamgoz, M. B. A., Fraser, S. P. & Brackenbury, W. J., 28 Oct Review article in Cancers. Ensembl ENSG n/a UniProt O O RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr 5: – Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is Aliases: HCN1, BCNG-1, BCNG1, EIEE24, HAC . Rationale: Voltage gated sodium channels (VGSCs) and acid sensing ion channels (ASICs) contain multiple subunits from which Nav and ASIC1 which will be studied, respectively (23,24). Each of these channels with their respective subunits contributes to hyperexcitability and hypersynchrony in epilepsy (24).


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Developmental regulation of the voltage gated sodium channel in PC12G cells by Sandeep Raha Download PDF EPUB FB2

Voltage-gated sodium channels play an important role in excitable cells. They mediate an increase in Na + ion permeability thereby transmitting depolarising impulses rapidly throughout cells and cell networks (Catterall, ).These molecules are also thought to perform a pivotal role during CNS development since action potential propagation and excitatory Cited by:   Summary diagrams showing possible regulatory pathways controlling voltage-gated sodium channel (VGSC) expression/activity in cells by (a) hormones and (b) growth factors.

Some pathways mediate transcriptional activity; some actions are through the respective Cited by: Voltage-gated Na (Na v) channels are key regulators of neuronal mammalian genome encodes multiple Na v s, but reported channel kinetics greatly exceeds gene number.

Recent studies have identified a range of post-transcriptional modifications that, combined, are sufficient to generate diversity in channel kinetics and expression by: 1. Cardiac voltage-gated Na + channels (Na v) initiate the action potential (AP), are essential for conduction of the electrical impulses, and contribute to control the AP duration (Li et al.

).Na v is the α subunit of the principal Na + channel found in the heart. The pivotal role of Na v in normal cardiac function has been exemplified by the finding of numerous naturally occurring Cited by: Voltage-gated Na + channels (VGSCs) are heteromeric membrane protein complexes containing pore-forming α subunits in association with non-pore-forming β subunits (Figure 1) (Catterall, ).

The β subunits regulate channel gating and are also cell adhesion molecules (CAMs) (Brackenbury and Isom, ).Cited by: The role of Na + fluxes through voltage-gated sodium channels in the regulation of sperm cell function remains poorly understood.

Previously, we reported that several genes encoding voltage-gated Na + channels were expressed in human testis and mature spermatozoa. In this study, we analyzed the presence and function of the TTX-resistant VGSC α subunit Nav in human capacitated sperm by:   Abstract.

Voltage-gated sodium channels (Na V) are functionally expressed in highly metastatic cancer cells derived from nonexcitable epithelial tissues (breast, prostate, lung, and cervix).MDA-MB breast cancer cells express functional sodium channel complexes, consisting of Na V and associated auxiliary β-subunits, that are responsible for a sustained inward sodium.

Voltage-gated sodium channels are transmembrane proteins responsible for the initiation and propagation of action potentials.

One subtype, Na v (brain type III) is tetrodotoxin sensitive and fast inactivated. Na v has been shown to be expressed at low levels in the adult rat, but to be upregulated after sciatic nerve axotomy in the dorsal root by:   Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage.

Pore-forming Na v α proteins in cancer cells. The first descriptions of voltage-dependent sodium currents, and therefore of the functional expression of Na V α proteins at the plasma membrane of cancer cells, and the hypotheses that they could participate in the oncogenic process came in the late 's.

In these pioneer works voltage-gated sodium currents were initially recorded in Cited by:   Structure of voltage-gated sodium channels. (a) Schematic representation of the sodium-channel subunits. The α subunit of the Na v channel is illustrated together with the β1 and β2 subunits; the extracellular domains of the β subunits are shown as immunoglobulin-like folds, which interact with the loops in the α subunits as shown.

Roman numerals indicate the Cited by: The voltage-gated sodium channel Na(V) is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons.

Voltage-gated sodium channels are thus likely to associate in a ternary complex containing neurofascin/NrCAM, and ankyrin-G. Mice with no ankyrin- G expression in the cerebellum exhibit loss of ability of Purkinje neurons to fire action potentials, as well as loss of restriction of neurofascin/NrCAM to axon initial segments Cited by: Regulation of voltage-gated sodium channel expression in cancer: Hormones, growth factors and Available via license: CC BY Content may be subject to copyright.

Developmental regulation of sodium channel expression in the rat forebrain Article (PDF Available) in Journal of Biological Chemistry (18). VGNaC in breast cancer cells. A, sodium current-voltage relationship of MDA-MB cells. The inset on the left shows a family of currents recorded from a cell depolarised, from a holding.

Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation Research output: Contribution to journal › Article Therapeutic potential for phenytoin: targeting Na v sodium channels to reduce. Voltage-gated Na+ channels (VGSCs) are comprised of a pore-forming α subunit typically in association with one or more smaller β subunits (Figure 1).1 The β subunits regulate channel expression and gating, and are immunoglobulin (Ig) superfamily cell adhesion molecules (CAMs).2 VGSCs are classically responsible for.

inhibitory neurotransmitters binds to postsynaptic chemically gated chloride channels. chloride moves from outside the cell to inside.

the inside of the postsynaptic cells becomes negative. the local chloride current becomes weaker as it moves toward the axon hillock.

Abstract. Voltage-gated sodium channels (Na v) underlie the activity of many excitable the heart, Na v channels are responsible for the rapid cardiomyocyte action potential upstroke that promotes rapid conduction of the electrical impulse leading to coordinated mechanical contraction.

Central to this function, Na v channels activate (and then inactivate) rapidly in. Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein complexes containing pore-forming α subunits in association with non-pore-forming β subunits (Figure 1) (Catterall, ).

The β subunits regulate channel gating and are also cell adhesion molecules (CAMs) (Brackenbury and Isom, ). The classical role of VGSCs is the. Because voltage‐gated Na + currents, including the transient, resurgent and persistent currents, are known to play important roles in generating spontaneous action potentials, the developmental changes in these currents were examined.

A large increase in the density of transient current, resurgent current and persistent current was observed Cited by: The voltage gated sodium channels undergo changes in activity during the depolarization phase of an action potential. Name the sequence of events from first to last.

1) A graded potential depolarizes the initial segment. The region of a neuron with voltage-gated sodium channels is the: Axon Hillock.

Neurons are classified on the basis of their structure as: sensory, association. The two major cell populations of the neural tissue are. Neurons and neuroglia.

The types of glial cells in the CNS are: Astrocytes, oligodendrocytes, microglia, ependymal cells. Description This book discusses voltage-gated ion channels and their importance in drug discovery and development.

The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in.

Voltage-gated sodium channels beta 2 (Navβ2, encoded by SCN2B) is a substrate of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and regulates cell surface expression of channels.

Diversity. Voltage-gated sodium channels normally consist of an alpha subunit that forms the ion conduction pore and one to two beta subunits that have several functions including modulation of channel gating.

Expression of the alpha subunit alone is sufficient to produce a functional channel. Voltage-Gated Sodium Channels P-loops were part of the TTX binding site and likely to be the outer pore mouth.

The cardiac isoform of the sodium channel (Nav) is known to be dramatically less sensitive to TTX block, but only two residues in the lining of the putative outer vestibule are different.

Splice variants, channel editing, post-translational modification and association with accessory proteins all may amplify the repertoire of voltage-gated sodium channels. Using adult inducible knockouts of the various components of sodium channel complexes should provide invaluable information for defining new targets for therapeutic Author: John N.

Wood. All of the cells in our body are made from a book of blueprints contained in: Sodium channels close when the membrane potential reaches approximately +30 mV.

Voltage-gated calcium ion channels that function in neurotransmission are primarily found on the. Voltage-gated sodium channels play a crucial role in regulating the electrical excitability of animal cells, being primarily responsible for the depolarization phase of the action potential.

The channel consists of a highly pro-cessed a subunit that is approximately kDa, and is associated with one or more accessory subunits (b1, b2File Size: KB.

Section 1 Structural and Molecular Bases of Ion Channel Function. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart.

Voltage-Gated Calcium. Voltage-Gated Potassium Channels. Structural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel Function. Mammalian Calcium Pumps in Health and Disease.

The axon initial segment (AIS) is a specialized region in neurons where action potentials are initiated. It is commonly assumed that this process requires a high density of voltage-gated sodium Cited by: This book discusses voltage-gated ion channels and their importance in drug discovery and development.

The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk. Abstract.

Voltage-gated sodium channels (Na v s) are essential for the initiation and propagation of action potentials in most excitable tissues, such as neurons or cardiac myocytes. Mutations in Na v s are linked to several severe conditions, such as pain syndromes, epilepsy, and cardiac arrhythmias and these ion channels are therefore among the most Cited by: 1.

(4) An investigator studying the function of voltage gated sodium channel develops a mutant from of the channel that inactivates more rapidly than normal.

which of the following is the most likely effect of this mutation on the electrical properties of the neuron. a)increases the amlitutde of the action potential. Tetrodotoxin is a sodium channel inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions (responsible for the rising phase of an action potential) into the neuron.

This prevents the nervous system from carrying messages and thus muscles from contracting CAS Number: type of ion channel allowing Ca2+ in and out. Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the calcium ion Ca 2+.OPM protein: 6c Bingjun He and David M.

Soderlund, Functional Expression of Rat Nav Voltage-Gated Sodium Channels in HEK Cells: Modulation by the Auxiliary β1 Subunit, PLoS ONE, /, 9, 1, (e), ().Cited by: Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.

Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as s: SCN1B, ATFB13, BRGDA5, GEFSP1.

The purpose of the present section is to provide an overview of the characterized partners of the main cardiac sodium channel, Na Vinvolved in regulating the functional expression of this channel both in terms of trafficking and targeting into by: 5.Kv (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the KCNQ1 gene.

K v is a voltage-gated potassium channel present in the cell membranes of cardiac tissue and in inner ear neurons among other tissues. In the cardiac cells, K v mediates the I Ks (or slow delayed rectifying K +) Aliases: KCNQ1, ATFB1, ATFB3, JLNS1, KCNA8.

The voltage-gated sodium ion channel (VGSC) belongs to the largest superfamily of ion channels. Since VGSCs play key roles in physiological processes they are major targets for effective by: